FLT3 (phospho Y591) polyclonal antibody
产品名称： FLT3 (phospho Y591) polyclonal antibody
英文名称： FLT3 (phospho Y591) polyclonal antibody
产品编号： PAB16970
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of FLT3.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding Y591 of human FLT3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody detects endogenous levels of FGFR1 only when phosphorylated at tyrosine 530.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Signaling networks assembled by oncogenic EGFR and c-Met.
Guo A, Villen J, Kornhauser J, Lee KA, Stokes MP, Rikova K, Possemato A, Nardone J, Innocenti G, Wetzel R, Wang Y, MacNeill J, Mitchell J, Gygi SP, Rush J, Polakiewicz RD, Comb MJ.Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):692-7. Epub 2008 Jan 7.
- 2.
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ.Cell. 2007 Dec 14;131(6):1190-203.
- 3.
- Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1.
Sanguinetti AR, Cao H, Corley Mastick C.Biochem J. 2003 Nov 15;376(Pt 1):159-68.
- Entrez GeneID:
- 2322
- Protein Accession#:
- P06241
- Gene Name:
- FLT3
- Gene Alias:
- CD135,FLK2,STK1
- Gene Description:
- fms-related tyrosine kinase 3
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
- Other Designations:
- CD135 antigen,FL cytokine receptor,FLT3 receptor tyrosine kinase,OTTHUMP00000042340,fetal liver kinase 2,growth factor receptor tyrosine kinase type III,stem cell tyrosine kinase 1,tyrosine-protein kinase receptor FLT3
- Related Disease
- Acute Disease
- Cardiovascular Diseases
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Diabetes Mellitus, Type 2
- Disease Progression
- Down Syndrome
- Edema
- Fractures, Spontaneous
- Genetic Predisposition to Disease
- Leukemia
- Leukemia, B-Cell, Acute
- Leukemia, chronic myeloid
- Leukemia, Lymphocytic, Acute, L1
- Leukemia, Myelocytic, Acute
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Acute
- Leukemia, Myelomonocytic, Chronic